Vectalys’ know how

Vectalys provides highly purified and super concentrated lentiviral vectors that efficiently transfer genes into a wide variety of mammal cells for gene over expression or gene silencing.

Expertise in lentiviral vector production since 2005

Using its own proprietary technology, Vectalys has developed three production and purification processes to provide the right lentiviral vectors for the right application. Since the creation of the company in 2005, we have generated more than 4000 lentiviral vectors batches for many customer applications.

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A unique patented purification process

Vectalys differs from all other lentiviral vectors producers by its purification offers adapted to client projects.

Using classical production processes, the proteins impurities co-purified with lentiviral vectors are responsible for toxicity observed in target cells after transduction.

Through a patented process involving serum and antibiotic free media and followed by several purification steps, Vectalys obtains the removal of 99% of proteins and DNA impurities. Vectalys provides the highest purity on the market.

These purification steps avoid phenotype changes or specific cell responses. The resulting high quality of lentiviral vectors allows to efficiently transduce delicate cells or hard to transfect cells.

Purification of lentiviral vectors

A robust and strong titration method

Differences TU PP

The lentiviral vectors titer in TU/ml we provide represents the true count of efficient particles that our customer can use for their experiments. Most of our competitors do not provide titers in TU/ml units but the full count of particles, including damaged or empty particles which bring nothing but toxicity to the target cells.

During the production of viral vectors, functional and nonfunctional particles are produced. A functional and complete particle is called a transduction unit (TU). Physical Particles (PP) represent functional particles and also non functional particles including empty particles, damaged particles and free p24 proteins. The PP/TU ratio is a good measure of the quality of the vector produced.

To increase the ratio of functional particles, it is optimal to reduce the production of PP in the viral supernatants. This is another advantage of having a reliable and discriminating titration method for the different types of particles.

An attentive and expert customer support team

Vectalys is a real partner and brings expertise in project management, scientific design, project follow-up and quality of the results. The level of implication of Vectalys is dependent on our customer’s demand, from simply delivering a vector production to partnering on the whole project. Vectalys’ scientific team supports you for the whole duration of your project in order to provide the right vector for the right application. In all cases, Vectalys will help you define the best lentiviral vector batch to transduce your target cells with 100% efficiency.

Vectalys has very qualified and committed scientists, they deliver on what they promise. It's always a pleasure to work with them and their products.
Urs Lüthi, Associate Director and Deputy Head HTS at Idorsia Pharmaceuticals Ltd

Vectalys lentiviral batches have always been at the highest standard with excellent support from the scientific team: that has been a real asset for conducting our research projects over the years!
Thomas Moreau, Research Associate at University of Cambridge

"Vectalys has proposed effective solutions to all the problems encountered in the production of our viruses. They have been of great help in implementing our project."
Pierre, Team Leader

Vectalys team is a great support and technical expertise to answer about ours projects
Guillaume, preclinical researcher in neurosciences

Since we work with Vectalys, we have always had full satisfaction of Vectalys products
Yara Barreira, Unit director at INSERM

Thank you and all the staff at Vectalys for the great help at any level of the project.
Giuseppe, Head of Neuroscience, Italy

I would like to thank you again for your clear, efficient and successful work plan. It has been a very positive experience!
Janette, Scientist, UK

I thank you for the service Vectalys provided us and will for sure advertise it in the near future to our research network
Marc, Senior Scientist, Switzerland

Our offer

Three levels of purification to fit your project

Vectalys provides custom lentiviral vectors with three levels of purification according to your target cells. 

Lentiviral vector offer

Vectalys Premium also exists in large scale batches (from 5 to 25ml)

Vectalys provides large-scale productions of lentiviral vectors (from 5 to 25ml) with the same quality and purity as small scale Vectalys premium batches.