Local genetic modification

Although well-established, the use of transgenic animals for applications such as the validation of candidate genes is time-consuming, costly and changes may be lethal to the developing embryos.

Vectalys offers an innovative approach to the study of disease models in vivo

  • Save time and costs - ready to use models developed within 2 months
  • Study response of target tissue without stimulating a compensatory physiological response
  • Use adult animals that may better represent the disease state/response
  • Utilize a tissue-specific transduced animal model to save time and costs prior to establishing the transgenic model.

Customer projects we have been involved with:

  • CNS
  • Hematopoietic model
  • Urological model
  • . . .

Why Vectalys lentiviral vectors?

Vectalys lentiviral vectors allow the gene delivery into dividing and non-dividing cells creating a unique tool from in vitro to in vivo studies. Vectalys lentiviral vectors are used to transduce tissues such as brain, lung, muscle or bone, creating tissue specific disease models in adult animals:

  • The Vectalys patented lentiviral vectors do not affect the viability and the proliferation of your target cells.
  • Vectalys lentiviral vectors ensure that the integration events occur in every cells – 100% transduction efficiency on primary cells and stem cells.
  • Vectalys lentiviral vectors enable to manage a dose effect on gene of interest (G.O.I.) expression by controlling the M.O.I.
  • Vectalys lentiviral vectors eliminate needs for antibiotic resistance selection steps

At Vectalys, we provide full teams of experts in cells engineering to support you and to fit the best your projects. We will help you to design the best experimental protocol for your gene delivery project.

Publications

  • Weber A, Groyer-Picard MT, Dagher I. Hepatocyte Transplantation Techniques: Large Animal Models. In: Hepatocyte Transplantation: Methods and Protocols. Humana press, 2009, vol. 481.
  • Dagher I, Nguyen TH, Groyer-Picard MT, Lainas P, Mainot S, Guettier C, Pariente D, Franco D, Weber A. Efficient hepatocyte engraftment and long-term transgene expression after reversible portal embolization in nonhuman primates. Hepatology, 2009, 49 (3): 950-959.